Jennifer Aniston as Justine Last

John C. Reilly as Phil Last

Jake Gyllenhaal as Holden Worther

Zooey Deschanel as Cheryl

Deborah Rush as Gwen Jackson

Mike White as Corny

John Carroll Lynch as Jack Field, Your Store Manager

Tim Blake Nelson as Bubba

John Doe as Mr. Worther

Roxanne Hart as Mrs. Worther

Aimee Garcia as Nurse

Annie O'Donnell as Haggard Woman

Jon Shere as Lester

Alice Amter as Big Haired Woman

Jean Rhodes as Old Woman

Lalo Guerrero as Blackberry Vendor

Michael Hyatt as Floberta

Enzo as Bits

Ken Rudulph as Reporter

Jacquie Barnbrook as Heavy Set Woman