Will Ferrell as Ted (Man with the Yellow Hat) (voice)

Drew Barrymore as Maggie (voice)

David Cross as Junior (voice)

Eugene Levy as Clovis (voice)

Joan Plowright as Ms. Plushbottom (voice)

Dick Van Dyke as Mr. Bloomsberry (voice)

Frank Welker as George (voice)

Ed O'Ross as Ivan (voice)

Michael Chinyamurindi as Edu (voice)

Michael Sorich as "Seen It" Cab Driver (voice)

Billy West as Manager (voice)

Jeff Bennett as Salesman (voice)

Kath Soucie as Animal Control Receptionist (voice)

Clint Howard as Balloon Man (voice)

Shane Baumel as Kid (voice)

Timyra-Joi Beatty as Kid (voice)

Christopher Chen as Kid (voice)

Jessie Flower as Kid (voice)

Alexander Gould as Kid (voice)

Terrence Hardy Jr. as Kid (voice)

Hailey Noelle Johnson as Kid (voice)

Kelsey Lansdowne as Kid (voice)

Ariel Winter as Kid (voice)

Kimberly Brooks as Additional Voices (voice)

Wendy Cutler as Additional Voices (voice)

Joey D'Auria as Additional Voices (voice)

Richard Epcar as Additional Voices (voice)

Treva Etienne as Additional Voices (voice)

Eddie Frierson as Additional Voices (voice)

Donald Fullilove as Additional Voices (voice)

Philip Maurice Hayes as Additional Voices (voice)

Bridget Hoffman as Additional Voices (voice)

Rif Hutton as Additional Voices (voice)

Steve Kehela as Additional Voices (voice)

Grier King as Additional Voices (voice)

Donna Lynn Leavy as Additional Voices (voice)

Nadia Lewis as Additional Voice (voice)

John Mariano as Additional Voices (voice)

Caitlin McKenna as Additional Voices (voice)

Kerry Michele as Additional Voice (voice)

Juan Pope as Additional Voices (voice)

Jonny Solomon as Additional Voices (voice)

Mandy Fabian as Additional Voices (voice)

Fred Tatasciore as Additional Voices (voice)