Patrick Dempsey as Kenai (voice)

Mandy Moore as Nita (voice)

Jeremy Suarez as Koda (voice)

Rick Moranis as Rutt (voice)

Dave Thomas as Tuke (voice)

Andrea Martin as Anda (voice)

Catherine O'Hara as Kata (voice)

Wanda Sykes as Innoko (voice)

Wendie Malick as Aunt Siqiniq (voice)

Kathy Najimy as Aunt Taqqiq (voice)

Michael Clarke Duncan as Tug (voice)

Jim Cummings as Bering / Chilkoot (voice)

Jeff Bennett as Additional Voices (voice)

Jessie Flower as Additional Voices (voice)

Jack Weber as Additional Voices (voice)

Tress MacNeille as Additional Voices (voice)