Amy Poehler as Joy (voice)

Maya Hawke as Anxiety (voice)

Kensington Tallman as Riley (voice)

Liza Lapira as Disgust (voice)

Tony Hale as Fear (voice)

Lewis Black as Anger (voice)

Phyllis Smith as Sadness (voice)

Ayo Edebiri as Envy (voice)

Lilimar as Valentina (voice)

Grace Lu as Grace (voice)

Sumayyah Nuriddin-Green as Bree (voice)

Adèle Exarchopoulos as Ennui (voice)

Diane Lane as Mom (voice)

Kyle MacLachlan as Dad (voice)

Paul Walter Hauser as Embarrassment (voice)

Yvette Nicole Brown as Coach Roberts (voice)

Ron Funches as Bloofy (voice)

James Austin Johnson as Pouchy (voice)

Yong Yea as Lance Slashblade (voice)

Steve Purcell as Deep Dark Secret (voice)

Dave Goelz as Mind Cop Frank (voice)

Kirk R. Thatcher as Foreman (voice)

Frank Oz as Mind Cop Dave (voice)

Paula Pell as Mom's Anger (voice)

June Squibb as Nostalgia (voice)

Pete Docter as Dad's Anger (voice)

Paula Poundstone as Forgetter Paula (voice)

John Ratzenberger as Fritz (voice)

Sarayu Blue as Margie (voice)

Flea as Jake (voice)

Bobby Moynihan as Forgetter Bobby (voice)

Kendall Coyne Schofield as Hockey Announcer (voice)