Steve Carell as Gru (voice)

Kristen Wiig as Lucy (voice)

Will Ferrell as Maxime (voice)

Sofía Vergara as Valentina (voice)

Miranda Cosgrove as Margo (voice)

Dana Gaier as Edith (voice)

Madison Polan as Agnes (voice)

Pierre Coffin as Minions (voice)

Chris Renaud as Principal Übelschlecht (voice)

Steve Coogan as Silas (voice)

Stephen Colbert as Perry Prescott (voice)

Chloe Fineman as Patsy Prescott (voice)

Joey King as Poppy Prescott (voice)

Laraine Newman as Melora / Additional Voices (voice)

John DiMaggio as Bus Driver (voice)

Tara Strong as Additional Voices (voice)

Romesh Ranganathan as Additional Voices (voice)

Brad Ableson as Additional Voices (voice)

Barbara Harris as Additional Voices (voice)

Eden Boulton as Additional Voices (voice)

JP Karliak as Additional Voices (voice)

Cathy Cavadini as Additional Voices (voice)

Arif S. Kinchen as Additional Voices (voice)

Will Collyer as Additional Voices (voice)

Jeremy Maxwell as Additional Voices (voice)

Abby Craden as Additional Voices (voice)

Ken Daurio as Additional Voices (voice)

Khary Payton as Additional Voices (voice)

John DeMita as Additional Voices (voice)

Aaron Fors as Additional Voices (voice)

Isaac Robinson-Smith as Additional Voices (voice)

Willow Geer as Additional Voices (voice)

Isa Hall as Additional Voices (voice)

Nisa Ward as Additional Voices (voice)

Aaron Hendry as Additional Voices (voice)

Andreana Weiner as Additional Voices (voice)

Colette Whitaker as Additional Voices (voice)