Ryan Reynolds as Wade Wilson / Deadpool / Nicepool

Hugh Jackman as Logan / Wolverine

Emma Corrin as Cassandra Nova

Matthew Macfadyen as Mr. Paradox

Dafne Keen as Laura / X-23

Jon Favreau as Happy Hogan

Morena Baccarin as Vanessa

Rob Delaney as Peter

Leslie Uggams as Blind Al

Jennifer Garner as Elektra

Wesley Snipes as Blade

Channing Tatum as Gambit

Chris Evans as Johnny Storm

Henry Cavill as The Cavillrine

Wunmi Mosaku as B-15

Aaron Stanford as Pyro

Tyler Mane as Sabretooth

Karan Soni as Dopinder

Brianna Hildebrand as Negasonic Teenage Warhead

Shioli Kutsuna as Yukio

Stefan Kapičić as Colossus (voice)

Randal Reeder as Buck

Lewis Tan as Shatterstar

Nick Pauley as Dancepool

Sonita Henry as Mrs. Chipman

Ryan McKen as Mr. Chipman

Nanak Phlora as Elliot Chipman

Aydin Ahmed as Kevin Chipman

Leemore Marrett Jr. as Minuteman Leader

James Dryden as TVA Tech

Ollie Palmer as Bar Patron

Greg Hemphill as Seedy Bartender

Aaron W Reed as Juggernaut

Mike Waters as Blob

Rob Mac as TVA Soldier

James Reynolds as Screaming Mutant (voice)

Ed Kear as Outpost Tech

Paul G. Raymond as TVA Office Agent

Blake Lively as Ladypool (voice)

Inez Reynolds as Kidpool (voice)

Nathan Fillion as Headpool (voice)

Matthew McConaughey as Cowboypool (voice)

OIin Reynolds as Babypool (voice)

Paul Mullin as Welshpool

Alex Kyshkovych as Canadapool

Billy Clements as Russian (uncredited)

Daniel Medina Ramos as Toad (uncredited)

Jade Lye as Lady Deathstrike (uncredited)

Nilly Cetin as Quill (uncredited)

Eduardo Gago Muñoz as Azazel (uncredited)

Chloe Kibble as Callisto (uncredited)

Curtis Rowland Small as Bullseye (uncredited)

Ayesha Hussain as Psylocke (uncredited)

Jessica Walker as Arclight (uncredited)

Harry Holland as Haroldpool (uncredited)

Kevin Fortin as Zenpool (uncredited)

Luke Bennett as Comic-Accurate Wolverine Body Double (uncredited)