Paul Fusco as ALF (voice)

Miguel Ferrer as Dexter Moyers

William O'Leary as Capt. Rick Mullican

Jensen Daggett as Maj. Melissa Hill

Martin Sheen as Colonel Gilbert Milfoil

Ray Walston as Motel Manager

Scott Michael Campbell as 2nd Lt. Harold Reese

Beverly Archer as Dr. Carnage

Charles Robinson as Dr. Stanley

John Schuck as Gen. Myron Stone

Gregory Alan Williams as Police Officer

Liz Coke as Nina

Dell Yount as Dr. Mockton

Dennis Creaghan as Nigel Neville

Lenny Wolpe as Dr. Newman

Erick Avari as Rocket (voice)

Michael D. Weatherred as Murphy

Markus Redmond as Sgt. Rhomboid

Ed Begley Jr. as Dr. Warner

Lee Arenberg as Gate Guard

Jeremiah Birkett as Pete Meatman

W. Earl Brown as Ernie

Anne Gee Byrd as Farsworth

John Dunbar as Man #1

Billy Keane as Card Guard #1

Michael Laskin as Undermeyer

Randy Oglesby as Bouncer

F.J. Rio as S.P.

Lin Shaye as Waitress

Kim Strauss as Assistant

Lynn Tufeld as Cocktail Waitress

Ahmet Zappa as Card Guard #2

Ken Byers as Waiter