Steve Martin as Tom Baker

Bonnie Hunt as Kate Baker

Piper Perabo as Nora Baker

Tom Welling as Charlie Baker

Hilary Duff as Lorraine Baker

Kevin G. Schmidt as Henry Baker

Alyson Stoner as Sarah Baker

Jacob Smith as Jake Baker

Liliana Mumy as Jessica Baker

Morgan York as Kim Baker

Forrest Landis as Mark Baker

Blake Woodruff as Mike Baker

Brent Kinsman as Nigel Baker

Shane Kinsman as Kyle Baker

Paula Marshall as Tina Shenk

Steven Anthony Lawrence as Dylan Shenk

Alan Ruck as Bill Shenk

Richard Jenkins as Shake

Holmes Osborne as Nick Gerhard

Vanessa Bell Calloway as Diana Philips

Rex Linn as Coach Bricker

David Kelsey as Assistant Coach

Dax Shepard as Camera Crew Member

Elon Gold as Camera Crew Member #2

Cody Linley as Quinn

Adam Taylor Gordon as Cooper

Julie Araskog as Radio Talk Show Host

Benjamin Fitch as Reporter

Antonio Vega as Police Officer

David Bowe as TV Interviewer

Kevin Carey as Reporter #2

Ossie Mair as Cabbie

Amy Hill as Miss Hozzie

Ted Rooney as Principal

Joel McCrary as Gil

Tiffany Dupont as Beth

Shawn Levy as Press Room Reporter

Dylan S. Shults as Party Kid

Regis Philbin as Regis Philbin

Kelly Ripa as Kelly Ripa

Merris Carden as Teen Nora Baker (uncredited)

Wayne Knight as Electrician (uncredited)

Ashton Kutcher as Hank (uncredited)

Jared Padalecki as Bully (uncredited)

Gary Pike as Doctor (uncredited)

D. Danny Warhol as Football Player #65 (uncredited)