Steve Martin as Tom Baker

Eugene Levy as Jimmy Murtaugh

Bonnie Hunt as Kate Baker

Tom Welling as Charlie Baker

Piper Perabo as Nora Baker-McNulty

Hilary Duff as Lorraine Baker

Carmen Electra as Sarina Murtaugh

Jaime King as Anne Murtaugh

Taylor Lautner as Eliot Murtaugh

Alyson Stoner as Sarah Baker

Jonathan Bennett as Bud McNulty

Jacob Smith as Jake Baker

Liliana Mumy as Jessica Baker

Morgan York as Kim Baker

Kevin G. Schmidt as Henry Baker

Forrest Landis as Mark Baker

Brent Kinsman as Nigel Baker

Shane Kinsman as Kyle Baker

Blake Woodruff as Mike Baker

Alexander Conti as Kenneth Murtaugh

Melanie Tonello as Becky Murtaugh

Robbie Amell as Daniel Murtaugh

Courtney Fitzpatrick as Lisa Murtaugh

Madison Fitzpatrick as Robin Murtaugh

Shawn Roberts as Calvin Murtaugh

William Copeland as The Commodore

Peter Keleghan as Mike Romanow

Sam Kalilieh as Doctor

Damon Runyan as Tennis Pro

Graham Losee as Theatre Usher

Seth Howard as Clam Bake Server

Matthew Knight as Theatre Kid

Lee MacDougall as Doobner Dad

Jenny Parsons as Doobner Mom

Dylan Rosenthal as Doobner Older Son

Haylee Wanstall as Doobner Daughter

Ely Henry as Doobner Younger Son

Tre Smith as Security Guard

Adam Shankman as Clam Bake Chef

Shawn Levy as Hospital Intern

Enid Rose as Announcer at Graduation

Kristen Dulmage as Clam Bake Piano Player

Ben Falcone as Theatre Patron

Kelly Keaton as Theatre Patron

Phillip Brock as Theatre Patron

Juliette Goglia as Theatre Patron

Sara Van Horn as Theatre Patron

Nancy Daly as Theatre Patron

Kathryn Joosten as Theatre Patron

Resmine Atis as Theatre Patron (uncredited)

John Eric Brown as Train passenger (uncredited)

Michael Comrie as Sailor (uncredited)

Jonathan Flanigan as EMT (uncredited)

Talia Russo as Lifeguard (uncredited)

Konstantin Shaburov as Waiter at the Party (uncredited)