Hilary Duff as Lizzie McGuire / Isabella Parigi

Adam Lamberg as David Gordon

Yani Gellman as Paolo Valisari

Alex Borstein as Miss Ungermeyer

Brendan Kelly as Sergei

Ashlie Brillault as Kate Sanders

Clayton Snyder as Ethan Craft

Jake Thomas as Matt McGuire

Jody Racicot as Giorgio

Hallie Todd as Jo McGuire

Robert Carradine as Sam McGuire

Carly Schroeder as Melina Bianco

Daniel Escobar as Mr. Escobar

Peter Kelamis as Dr. Comito

Katy Louise Saunders as Cute Girl #1

Ona Grauer as Model #1

Antonio Cupo as Model #2

Marcus Hondro as Janitor

Brent Chapman as Parent #1

Christine Lippa as Parent #2

Dan Joffre as Parent #3

Ilaria Tommasino as Small Child #2

Aaron Douglas as Paparazzo #2

Heather Laura Gray as Background Dancer

Morgan Tanner as Background Dancer

Evangeline Lilly as Police Officer

Paolo Giovannucci as Florista #1

Alessandro Cavalieri as Tour Bus Driver

Terra C. MacLeod as Franca