Chevy Chase as Clark Griswold

Beverly D'Angelo as Ellen Griswold

Anthony Michael Hall as Rusty Griswold

Imogene Coca as Aunt Edna

Randy Quaid as Cousin Eddie

Dana Barron as Audrey Griswold

Eddie Bracken as Roy Walley

Brian Doyle-Murray as Kamp Komfort Clerk

Miriam Flynn as Cousin Catherine

James Keach as Motorcycle Cop

Eugene Levy as Car Salesman

Frank McRae as Grover

John Candy as Lasky, Guard at Walleyworld

Christie Brinkley as Girl In The Red Ferrari

Jane Krakowski as Cousin Vicki

John P. Navin, Jr. as Cousin Dale

Nathan Cook as Man Giving Directions

Christopher Jackson as Pimp

Mickey Jones as Mechanic

John Diehl as Assistant Mechanic

Jeannie Dimter Barton as Dodge City Cashier

Randy Lowell as Wyatt Earp

Virgil Wyaco II as Indian

Gerry Black as Davenport

James Staley as Motel Desk Clerk

Adelaide Wilder as Car Hop

Tessa Richarde as Motel Guest

Fritz Ford as Neighbor

Eric Stacey as Neighbor

Scott Perry as Swat Leader

Dennis Freeman as Policeman

Michael Talbott as Cowboy

John Craigmile as Camel Rider

Henry Gibson as Hotel clerk (uncredited)

Harold Ramis as Car salesman (voice) (uncredited)