Dakota Fanning as Euphemia 'Effie' Gray

Emma Thompson as Lady Eastlake

Greg Wise as John Ruskin

Tom Sturridge as Everett Millais

Robbie Coltrane as Doctor

Julie Walters as Margaret Cox Ruskin

Derek Jacobi as Travers Twiss

Claudia Cardinale as Viscountess

David Suchet as Mr. Ruskin

James Fox as Sir Charles Eastlake

Patrick Doyle as Wedding Minister

Russell Tovey as George

Linda Bassett as Anna

Pip Torrens as Royal Academy / Times Journalist

Nicholas Jones as Doctor Lee

Joanna Hole as Mrs. McPhail (uncredited)

Riccardo Scamarcio as Rafael

Polly Dartford as Sophie Gray

Tom Herriott as William Holman Hunt

Sam Churchill as Dante Gabriel Rossetti

Martin Keatman as Thomas Woolner

Chris Haggart as William Michael Rossetti

Alex Best as James Collinson

George Laing as Frederic Stephens

Peter Farr as Mr. Gray

Nicola Draffan as Mrs. Gray

Saskia Keatman as Lady Rondell

Kelly Healey as Lady Dashwood

Frida Baranek as Duchess di Alba

Tigerlily Hutchinson as Young Effie, Borghese Gallery

Iain Marshall as Mr. McPhail