Rachel McAdams as Lisa Reisert

Cillian Murphy as Jackson Rippner

Brian Cox as Joe Reisert

Jayma Mays as Cynthia

Jack Scalia as Dep. Sec. Charles Keefe

Robert Pine as Bob Taylor

Terry Press as Marianne Taylor

Brittany Oaks as Rebecca

Laura Johnson as Blonde Woman

Max Kasch as Headphone Kid

Kyle Gallner as Headphone Kid's Brother

Angela Paton as Nice Lady

Loren Lester as Irate Passenger

Suzie Plakson as Senior Flight Attendant

Monica McSwain as Junior Flight Attendant

Dane Farwell as Hit Man at Dad's House

Beth Toussaint as Lydia Keefe

Adam Gobble as Keefe's Son

Megan Crawford as Keefe's Daughter

Carl Gilliard as Taxi Driver

Mary Kathleen Gordon as Airline Representative

Philip Pavel as Dallas Ticket Agent

Amber Mead as Dallas Ticket Agent

Dey Young as Dallas Gate Agent

Jeanine Jackson as Passenger with Iced Mocha

Carmen Gloria Pérez as Airline Passenger

Colby Donaldson as Keefe's Head Bodyguard

Jennie Baek as Keefe's Assistant

Amanda Young as Flight Attendant

Jim Lemley as Man on Fishing Boat

Jenny Wade as Coffee Shop Girl

Wes Craven as Airline Passenger (uncredited)