Luke Wilson as Mitch

Will Ferrell as Frank

Vince Vaughn as Beanie

Jeremy Piven as Pritchard

Ellen Pompeo as Nicole

Juliette Lewis as Heidi

Jerod Mixon as Weensie

Leah Remini as Lara

Perrey Reeves as Marissa

Patrick Cranshaw as Blue

Craig Kilborn as Mark

Elisha Cuthbert as Darcie

Seann William Scott as Peppers

Rick Gonzalez as Spanish

Matt Walsh as Walsh

Artie Lange as Booker

Patrick Fischler as Michael

Sara Tanaka as Megan

Harve Presnell as Mr. Springbrook

Katherine Ellis as Amy

Phe Caplan as Julie

Sarah Shahi as Erica

Kristen Kerr as Lisa

Dan Finnerty as Wedding Singer

Gregory Alan Williams as Therapist

Ashley Jones as Caterer

Bryan Callen as Waiter

James Carville as Himself

Todd Phillips as Gang Bang Guy

Stuart Cornfeld as Taxi Driver

Corinne Kingsbury as Jenny

Lisa Donatz as Jeanie

David Moreland as Convention Speaker

Chris Hendrie as Priest

Rachel Winfree as Archer's Wife

Nathalie Fay as Mindy

Kristina Hughes as Naked Woman

Nicholas Hosking as Naked Man

Sara Bryan as Amanda

Sydney Bryan as Amanda

Noel Gugliemi as Student #1

Robert Baker as Student #2

Bob Lazar as Marissa's Dad

Arthur Taxier as Professor

Darryl Armbruster as The Dan Band

Gene Reed as The Dan Band

David Arana as The Dan Band

David Hughes as The Dan Band

Marc Thaldorf as The Dan Band

Jimi Englund as The Dan Band

Snoop Dogg as Self

Warren G as Self

Bishop Don Magic Juan as Self

Kokane as Self

Matthew Carey as Hatch

Simon Helberg as Jerry

Abdul Goznobi as Abdul

Eddie Pepitone as Archer

Rob Corddry as Warren

Charles Noland as Beav

Raymond Ma as Mr. Ma

Jesse Heiman as Budnick

Joe Gonzales as Gonzo

Patrick J. Adams as Patch

Jake Jarvi as Jarvi

Ellen Cleghorne as Trustee (uncredited)

Andy Dick as Barry (uncredited)

Terry O'Quinn as Goldberg (uncredited)

David Michael White as Bullpen Pledge (uncredited)

Ray Buffer as Teacher (uncredited)

Candice T. Cain as College Student (uncredited)

Allen Bloomfield as Airplane Ticket Buyer (uncredited)

Katie Carlin as Wedding Guest (uncredited)