Robert De Niro as Don Lino (voice)

Martin Scorsese as Sykes (voice)

Will Smith as Oscar (voice)

Renée Zellweger as Angie (voice)

Jack Black as Lenny (voice)

Ziggy Marley as Ernie (voice)

Doug E. Doug as Bernie (voice)

Shelley Morrison as Mrs. Sanchez (voice)

David Soren as Shrimp (voice)

David P. Smith as Crazy Joe (voice)