John Travolta as James

Kirstie Alley as Mollie

Olympia Dukakis as Rosie

Elias Koteas as Stuart

Twink Caplan as Rona

Bruce Willis as Mikey (voice)

Roseanne Barr as Julie (voice)

Damon Wayans as Eddie (voice)

Gilbert Gottfried as Joey

Mel Brooks as Mr. Toilet Man (voice)

Lorne Sussman as Mikey

Megan Milner as Julie (1 year)

Georgia Keithley as Julie (4 months)

Nikki Graham as Julie (newborn)

Danny Pringle as Eddie

Neal Israel as Mr. Ross

Lesley Ewen as Debbie

Noelle Parker as Woman Client

Douglas Warhit as Man Client

Terry David Mulligan as IRS Inspector

Paul Shaffer as Taxi Businessman

Don S. Davis as Dr. Fleischer

Morris Panych as Arrogant Businessman

Alex Bruhanski as Needle Doctor

Dorothy Fehr as Blonde

Heather Lea Gerdes as Hot Babe on Fire Escape

Robin Trapp as Cool Chick

Rick Avery as Burglar

Stephen Dimopoulos as Fire Chief

Jimmy Galeota as Punk Baby

Frank Totino as Candy Man

Coleman Lumley as Blonde Baby

Constance Barnes McCansh as Sexy Dancer

Ruby J. Munro as Businessman's Babe

Mollie Heckerling as Mikey's Dream Friend

Alicia Mizel as Slob Child

Aaron Jefford as Businessman (uncredited)

Denis Corbett as Cop (uncredited)

Yolanda Corbett as Shopper (uncredited)

Jennifer Juniper Angeli as Earthmother (uncredited)