Will Ferrell as Jackie Moon

Woody Harrelson as Monix

André 3000 as Clarence

Maura Tierney as Lynn

Andy Daly as Dick Pepperfield

Will Arnett as Lou Redwood

Andy Richter as Bobby Dee

Rob Corddry as Kyle

Matt Walsh as Father Pat the Ref

Tim Meadows as Cornelius Banks

David Koechner as Commissioner

Jackie Earle Haley as Dukes

DeRay Davis as Bee Bee Ellis

Josh Braaten as Twiggy Munson

Jay Phillips as Scootsie Double Day

Peter Cornell as Vakidis

Pat Kilbane as Petrelli

Patti LaBelle as Jackie's Mom

Collette Wolfe as Melinda

Jason Sudeikis as Nacho Fan

Kristen Wiig as Bear Handler

Ellia English as Ms. Quincy

Ian Roberts as Spurs Coach

Phil Hendrie as Nets Coach

Ed Helms as Turtleneck

Brian Huskey as White Pants

Paul Rust as Wheelchair Darren

Charlyne Yi as Wheelchair Jody

Rashid Byrd as Tropics Player

Terrell Byrd as Tropics Player

Tyus Tillman as Tropics Player

Michael Westphal as Tropics Player

MaShae Alderman as Ball Girl

Briana Barran as Ball Girl

Karen Berg as Ball Girl

Charlie Gelbart as Ball Girl

Leigha Kingsley as Ball Girl

Kristin Pitts as Ball Girl

Jenica Robinson as Ball Girl

Erinn Selkis as Ball Girl

Sandy Sunshine as Ball Girl

Steve Seagren as Losing Owner #1

Gil Glasgow as Losing Owner #2

Noel Conlon as Man Being Hugged

Scot Armstrong as Cameraman

Steve Bannos as Cop at Jail

Anthony Burrell as Dancer

Dante Henderson as Dancer

Dan Domenech as Dancer

Kate Luyben as Staci Moon (uncredited)

Jerry Minor as Paul the DJ (uncredited)

Tiffany Michelle as Sarah (uncredited)

Charlie Koechner as Commissioner's Son (uncredited)

Gerard Averill as Gerard the Cop (uncredited)

Lyle Stevens as Duke's Buddy (uncredited)

Ralph Kampshoff as Indiana Pacers Owner (uncredited)

Warren Sweeney as Winning Team Owner #1 (uncredited)

Grayson Boucher as Spirits Player #31 / Spurs Player #22 (uncredited)

Bruno Sandoval as Spurs Player #41 (uncredited)

Byron de Marse as Spurs Player (uncredited)

Justen Naughton as Squires Player #31 (uncredited)

James Markham Hall Jr. as Squires Basketball Player (uncredited)

David Sampen as Squires Basketball Player (uncredited)

Kamal Moummad as Starting Point Guard (uncredited)

Quinn Hawking as Basketball player (uncredited)

Ryan C. Burney as Assist. Scoreboard Operator (uncredited)

Danny Mooney as Party Griller (uncredited)

David E. Brown as Avid Tropics Fan (uncredited)

Theo Caesar as Tropics Fan (uncredited)

Sarah Elizabeth Dell as Tropics Fan (uncredited)

Lili Asvar as Fan (uncredited)

Scotty Atkins as Fan (uncredited)

Scott Cordts as Spectator (uncredited)

Laurie Curtis as Spectator (uncredited)

Margaret Newborn as Spectator (uncredited)

Gary Teague as Spectator (uncredited)

Shawntay Dalon as Crowd Member (uncredited)