Bradley Cooper as Phil Wenneck

Ed Helms as Stu Price

Zach Galifianakis as Alan Garner

Justin Bartha as Doug Billings

Heather Graham as Jade

Sasha Barrese as Tracy Garner

Jeffrey Tambor as Sid Garner

Ken Jeong as Mr. Chow

Rachael Harris as Melissa

Mike Tyson as Mike Tyson

Mike Epps as Black Doug

Jernard Burks as Leonard

Rob Riggle as Officer Franklin

Cleo King as Officer Garden

Bryan Callen as Eddie Palermo

Matt Walsh as Dr. Valsh

Ian Anthony Dale as Chow's #1

Michael Li as Chow's #2

Sondra Currie as Linda

Gillian Vigman as Stephanie

Nathalie Fay as Lisa

Chuck Pacheco as Hotel Guest at Valet

Jesse Erwin as Hotel Valet

Dan Finnerty as Wedding Singer

Keith Lyle as Casino Dealer

Brody Stevens as Officer Foltz

Todd Phillips as Mr. Creepy

Mike Vallely as Neeco

James Martin Kelly as Police Clerk

Murray Gershenz as Felix

Andrew Astor as Eli

Casey Margolis as Budnick

Ken Flaherty as Old Timer at Gas Station

Joe Alexander as Pit Boss

Constance Broge as Woman in Elevator

Sue Pierce as Mini-Mart Cashier

Floyd Levine as Tailor

Robert A. Ringler as Minister

Britt Barrett as Bridesmaid

Chauntae Davies as Bridesmaid

Alisa Allapach as Bridesmaid

Nicholas Furu as Stun Gun Boy

Angelica Flameno as Stun Gun Girl

Lily Winn as Screaming Girl

Katerina Moutsatsou as Eddie's Assistant

Faleolo Alailima as Tyson's Bodyguard

Rio Ahn as Orderly (uncredited)

Joey Brander as Student (uncredited)

John Jason Bailey as Caesar's Palace Pimp (uncredited)

Cody Deal as Roman Soldier at Caesar's Palace (uncredited)

Natalie Cohen as Casino Guest (uncredited)

Carrie Keagan as Casino Guest (uncredited)

Stephanie Mathis as Casino Guest (uncredited)

Guile Branco as Casino Guest (uncredited)

Richard Alan Reid as Casino High Roller (uncredited)

Tom Spano as Casino High Roller (uncredited)

Lanette Fugit Hannah as High Roller (uncredited)

David Hill as Parent Driving Jaguar (uncredited)

Mitch Holleman as Max - Student (uncredited)

Jessica Simons as Casino Guest (uncredited)

Anthony Mingilino as Precision Driver (uncredited)

Michael A. Rizza as Guy in the Elevator (uncredited)

Charlene Geisler as Katie / Girl in the Elevator (uncredited)

Kaitlin Clark as Girl in Elevator (uncredited)

Heather Roop as Mom in Elevator (uncredited)

Joe Satriani as Guitarist in Wedding Band (uncredited)

Carrot Top as Himself (uncredited)

Jaira Valenti as Bartender Hostess (uncredited)

Anat Gerber as Cocktail Waitress (uncredited)

Victor Yerrid as Tiger (uncredited)