Abhishek Bachchan as Arjun Sen

Ahilya Bamroo as Reya

Pearle Dey as Child Reya

Jayant Kripalani as Dr. Jayanta Deb

Kristin Goddard as Nancy

Johnny Lever as Johnny

Ritesh Shah as Subodh

Arpita Chakrabarty as Sudheshna (Subodh's Wife)

Milan Awon as Arjun's Father

Anasua Kushari as Arjun's Mother

Indeepa Singh as Arjun's Ex-Wife

Daminee Basu as Dr. Shonali Bose

Tushar Sheetal Jain as Arjun's Brother

Caprice Ott as Nurse Chloe

Eliza Kim as Nurse Suzanne

Nathalie Zepek as Nurse post surgery

Bruce Gale as Dr. Savage

Tom McLaren as Dr. Tanner

Julia Megan Sullivan as Female Patient - Cancer Centre

Mike Sears as Bill (Arjun's Boss)

Nirvan Patnaik as Reya's Boyfriend

Joe Russell as Marc (Arjun's Lawyer)