Michael Fassbender as David / Walter

Katherine Waterston as Daniels

Billy Crudup as Oram

Danny McBride as Tennessee

Demián Bichir as Lope

Carmen Ejogo as Karine

Jussie Smollett as Ricks

Callie Hernandez as Upworth

Amy Seimetz as Faris

Nathaniel Dean as Hallett

Alexander England as Ankor

Benjamin Rigby as Ledward

Uli Latukefu as Cole

Tess Haubrich as Rosenthal

Lorelei King as Mother (voice)

Goran D. Kleut as Xenomorph / Neomorph

Andrew Crawford as Neomorph

Tom O'Sullivan as David / Walter Double

James Franco as Jacob Branson (uncredited)

Guy Pearce as Peter Weyland (uncredited)

Noomi Rapace as Dr. Elizabeth Shaw (uncredited)