Scarlett Johansson as Major Mira Killian / Motoko Kusanagi

Takeshi Kitano as Chief Daisuke Aramaki

Michael Pitt as Kuze / Hideo

Pilou Asbæk as Batou

Chin Han as Togusa

Juliette Binoche as Dr. Ouélet

Peter Ferdinando as Cutter

Rila Fukushima as Red Robed Geisha

Daniel Henshall as Skinny Man

Yutaka Izumihara as Saito

Anamaria Marinca as Dr. Dahlin

Kaori Momoi as Hairi

Lasarus Ratuere as Carlos Ishikawa

Danusia Samal as Ladriya

Tawanda Manyimo as Borma

Mana Hira Davis as Bearded Man

Erroll Anderson as Hanka Security Agent

Kai Fung Rieck as Diamond Face

Andrew Stehlin as No Pupils

Matthias Luafutu as Thick Built Yakuza

John Luafutu as Barkeep

Kaori Yamamoto as Young Motoko Kusanagi

Andrew Morris as Young Hideo

Adwoa Aboah as Lia

Chris Obi as Ambassador Kiyoshi

Makoto Murata as Yakuza Gunman

Natarsha Orsman as Oeulet's Assistant

Joseph Naufahu as Police Commander Johns

Vinnie Bennett as Rookie Cop

Pete Teo as Tony

Xavier Horan as Section Six Soldier

Allan Henry as Section Six Soldier

Bowie Chan Wing Wai as Yakuza

Kirt Kishita as Street Hustler

David Johnson Wood as Section Six Leader

Kate Venables as Geisha

Emma Coppersmith as Geisha

Tanya Drewery as Geisha

Hannah Tasker-Poland as Geisha

Jacqueline Lee Geurts as Geisha

Shinji Ikefuji as Kinsana

Michael Wincott as Dr. Osmond

Tricky as Senior Monk

Philippe Joly as Section 6 soldier

Yasushi Asaya as Yakuza (uncredited)

Jack Machiela as Data Host (uncredited)