Ryan Reynolds as Gary / Gavin / Gabriel

Melissa McCarthy as Margaret / Melissa / Mary

Hope Davis as Sarah / Susan / Sierra

Elle Fanning as Noelle

David Denman as Parole Officer/ Agitated Man

Octavia Spencer as Streetwalker

Ben Falcone as Ben Falcone

Dahlia Salem as Dahlia Salem

John Gatins as John Gatins

Lorene Scafaria as Game Night Guest

Rawson Marshall Thurber as Game Night Guest

Jim Rash as Game Night Guest