Elliot Page as Sylvia Likens

Catherine Keener as Gertrude Baniszewski

Hayley McFarland as Jennifer Faye 'Jennie' Likens

Nick Searcy as Lester Likens

Romy Rosemont as Betty Likens

Ari Graynor as Paula Baniszewski

Scout Taylor-Compton as Stephanie Baniszewski

Tristan Jarred as Johnny Baniszewski

Hannah Leigh as Shirley Baniszewski

Bradley Whitford as Prosecutor

James Franco as Andy

Scott Eastwood as Eric

Michael O'Keefe as Reverend Bill Collier

Carlie Westerman as Marie Baniszewski

Michelle Benes as Hope Orbach

Jeremy Sumpter as Coy Hubbard

Brian Geraghty as Bradley

Channing Nichols as Patty

Michael Welch as Teddy

Evan Peters as Ricky Hobbs

Amy Ferguson as Sally

Will Carter as Officer Waters

Edward James Gage as Bailiff

Patricia Place as Mrs. Doyle

Paul Grace as Cottin Candy Vendor (uncredited)

James Meehan as Defense Attorney (uncredited)

Paul Palo as Newspaper Reporter (uncredited)

Gary Sievers as Carnie (uncredited)