Frank Welker as Scooby-Doo / Fred Jones (voice)

Casey Kasem as Shaggy Rogers (voice)

Mindy Cohn as Velma Dinkley (voice)

Grey DeLisle as Daphne Blake (voice)

Ron Perlman as Captain Skunkbeard / Biff Wellington (voice)

Freddy Rodríguez as Rupert Garcia (voice)

Tim Conway as Skip Jones (voice)

Edie McClurg as Peggy Jones / Sea Salt Sally (voice)

Kathy Najimy as Sunny St. Cloud (voice)

Arsenio Hall as Captain Crothers (voice)

Dan Castellaneta as Mr. Mysterio / Woodenleg Wally (voice)