Casey Kasem as Shaggy Rogers (voice)

Frank Welker as Fred Jones / Scooby-Doo (voice)

Mindy Cohn as Velma Dinkley (voice)

Grey DeLisle as Daphne Blake / Natasha (voice)

Christine Baranski as Amelia von Butch (voice)

Ajay Naidu as Prince Omar (voice)

Ron Perlman as Hotep / Ancient One #2 (voice)

Jeremy Piven as Rock Rivers (voice)

Wynton Marsalis as Campbell (voice)

Oded Fehr as Amahl Ali Akbar (voice)

Virginia Madsen as Cleopatra (voice)