Molly Shannon as Peggy

Laura Dern as Bret

Regina King as Layla

Tom McCarthy as Pier

Josh Pais as Robin

John C. Reilly as Al

Peter Sarsgaard as Newt

Dale Godboldo as Don

Liza Weil as Trishelle

Amy Schlagel as Lissie

Zoe Schlagel as Lissie

Ursula Brauner as Dog Owner

Susan Mackin as Susan

Inara George as Holly

Christy Moore as Al's Girlfriend

Audrey Wasilewski as Audrey

Brenda Canela as Brenda

Sonya Eddy as Nurse

Jon Shere as Pound Employee

Steve Berg as Steve