Jodie Foster as Clarice Starling

Anthony Hopkins as Dr. Hannibal Lecter

Scott Glenn as Jack Crawford

Ted Levine as Jame Gumb

Anthony Heald as Dr. Frederick Chilton

Brooke Smith as Catherine Martin

Diane Baker as Senator Ruth Martin

Kasi Lemmons as Ardelia Mapp

Frankie Faison as Barney

Tracey Walter as Lamar

Charles Napier as Lt. Boyle

Danny Darst as Sgt. Tate

Alex Coleman as Sgt. Pembry

Dan Butler as Roden

Paul Lazar as Pilcher

Ron Vawter as Paul Krendler

Roger Corman as FBI Director Hayden Burke

Lawrence A. Bonney as FBI Instructor

Lawrence T. Wrentz as Agent Burroughs

Don Brockett as Friendly Psychopath

Frank Seals Jr. as Brooding Psychopath

Stuart Rudin as Miggs

Maria Skorobogatov as Young Clarice

Jeffrie Lane as Clarice's Father

Leib Lensky as Mr. Lang

George 'Red' Schwartz as Mr. Lang's Driver

Jim Roche as TV Evangelist

James B. Howard as Boxing Instructor

Bill Miller as Mr. Brigham

Chuck Aber as Agent Terry

Gene Borkan as Oscar

Pat McNamara as Sheriff Perkins

Kenneth Utt as Dr. Akin

Adelle Lutz as TV Anchor Woman

Obba Babatundé as TV Anchor Man

George Michael as TV Sportscaster

Jim Dratfield as Sen. Martin's Aide

D. Stanton Miranda as 1st Reporter

Rebecca Saxon as 2nd Reporter

Cynthia Ettinger as Officer Jacobs

Brent Hinkley as Officer Murray

Steve Wyatt as Airport Flirt

David Early as Spooked Memphis Cop

Andre B. Blake as Tall Memphis Cop

Bill Dalzell as Distraught Memphis Cop

Chris Isaak as SWAT Commander

Daniel von Bargen as SWAT Communicator

Tommy Lafitte as SWAT Shooter

Josh Broder as EMS Attendant

Buzz Kilman as EMS Driver

Harry Northup as Mr. Bimmel

Lauren Roselli as Stacy Hubka

Lamont Arnold as Flower Delivery Man

John Hall as State Trooper (uncredited)

Ted Monte as FBI Agent (uncredited)

George A. Romero as FBI Agent in Memphis (uncredited)

John W. Iwanonkiw as Orderly (uncredited)

Robert W. Castle as Priest on Chilton's Plane (uncredited)

Chris McGinn as Autopsy Victim (uncredited)

Gary Goetzman as Guido Paonessa (uncredited)