Salma Hayek Pinault as Frida Kahlo

Alfred Molina as Diego Rivera

Mía Maestro as Cristina Kahlo

Patricia Reyes Spíndola as Matilde Kahlo

Diego Luna as Alejandro

Roger Rees as Guillermo Kahlo

Ashley Judd as Tina Modotti

Antonio Banderas as David Alfaro Siqueiros

Edward Norton as Nelson Rockefeller

Saffron Burrows as Gracie

Geoffrey Rush as Leon Trotsky

Margarita Sanz as Natalia Trotsky

Omar Rodríguez as André Breton

Lila Downs as Tango Singer

Valeria Golino as Lupe Marín

Karine Plantadit as Paris Chanteuse

Didi Conn as Waitress

Ivana Sejenovich as Chapingo Chapel Model

Lucia Bravo as Auditorium Model

Alejandro Usigli as Professor

Amelia Zapata as Maid

Fermín Martínez as Painter on Bus

Loló Navarro as Nanny

Roberto Medina as Dr. Farril

Martha Claudia Moreno as Woman at Wedding