Paul Mercier as Leon S. Kennedy (voice)

Alyson Court as Claire Redfield (voice)

Laura Bailey as Angela Miller (voice)

Roger Craig Smith as Curtis Miller (voice)

Crispin Freeman as Frederic Downing (voice)

Michael Sorich as Senator Ron Davis (voice)

Salli Saffioti as Ingrid Hunnigan (voice)

Michelle Ruff as Rani Chawla (voice)

Mary Elizabeth McGlynn as Rani's aunt (voice)

Steve Blum as Greg Glenn (voice)

Michael McConnohie as WilPharma CEO (voice)

Kirk Thornton as U.S. President (voice)

Cindy Robinson as Various (voice)

Dave Wittenberg as Various (voice)

Kari Wahlgren as Various (voice)

Kyle Hebert as Various (voice)

Barbara Goodson as Various (voice)

Keith Silverstein as Various (voice)

Yuri Lowenthal as Various (voice)

Megan Hollingshead as Various (voice)

Skip Stellrecht as Various (voice)

Troy Baker as Various (voice)

Karen Strassman as Various (voice)

JB Blanc as Various (voice)

Johnny Yong Bosch as Various (voice)

Derek Mears as Greg Glenn / G-Curtis (motion capture)