Hugh Jackman as Tomás / Tom Creo / Tommy

Rachel Weisz as Isabel / Izzi Creo

Ellen Burstyn as Dr. Lillian Guzetti

Mark Margolis as Father Avila

Stephen McHattie as Grand Inquisitor Silecio

Fernando Hernández as Lord of Xibalba

Cliff Curtis as Captain Ariel

Sean Patrick Thomas as Antonio

Donna Murphy as Betty

Ethan Suplee as Manny

Richard McMillan as Henry

Lorne Brass as Dr. Alan Lipper

Abraham Aronofsky as Lab Technician

Renee Asofsky as Lab Technician

Anish Majumdar as Dr. Spencer

Janique Kearns as Young Nurse

Boyd Banks as Dominican Monk

Alex Bisping as Foot Soldier Del Toro

Kevin Kelsall as Foot Soldier Rivera

Patrick Vandal as Foot Soldier Galleano

Marcello Bezina as Foot Soldier Borjes

Hugo Salvador Gutierrez Aguilar as Mayan Warrior

Eric Carmelo Valenzuela Batz as Mayan Warrior

Elfego Vinicio Pena Castellanos as Mayan Warrior

Jose Maria Tol Chan as Mayan Warrior

Benjamin Panjoj Cortez as Mayan Warrior

Juan Salvador Lares as Mayan Warrior

Jose Alfredo Conoz Macario as Mayan Warrior

Tomas Tol Nix as Mayan Warrior

Luis Alfredo Yac Noj as Mayan Warrior

Mateo Martin Perez as Mayan Warrior

Edson Vasquez Pixabaj as Mayan Warrior

Marvin Leonardo Raxtun Raxtun as Mayan Warrior

Tomas Morales Sacquic as Mayan Warrior

Santos Ajic Sapon as Mayan Warrior

Xaijil Sicajan as Mayan Warrior

Manuel Antonio Salvador Tol as Mayan Warrior

Tomas Salvador Tol as Mayan Warrior

Tomas Augustin Canil Ventura as Mayan Warrior

Carlos Enrique Ramos Xalcut as Mayan Warrior

Octavio Guadelupe Zabala Xitamul as Mayan Warrior