Ellen Burstyn as Sara Goldfarb

Jared Leto as Harry Goldfarb

Jennifer Connelly as Marion Silver

Marlon Wayans as Tyrone C. Love

Christopher McDonald as Tappy Tibbons

Louise Lasser as Ada

Marcia Jean Kurtz as Rae

Janet Sarno as Mrs. Pearlman

Suzanne Shepherd as Mrs. Scarlini

Joanne Gordon as Mrs. Ovadia

Charlotte Aronofsky as Mrs. Miles

Mark Margolis as Mr. Rabinowitz

Michael Kaycheck as Donut Cop

Jack O'Connell as Corn Dog Stand Boss

Chas Mastin as Lyle Russel

Ajay Naidu as Mailman

Sean Gullette as Arnold the Shrink

Samia Shoaib as Nurse Mall

Peter Maloney as Dr. Pill

Abraham Abraham as King Neptune

Aliya Campbell as Alice

Te'ron A. O'Neal as Young Tyrone

Denise Dowse as Tyrone's Mother

Bryan Chattoo as Brody

Eddie De Harp as Brody's Henchman Victor

Scott Franklin as Jailer (voice)

Peter Cheyenne as Sal the Geep

Brian Costello as First AD

Abraham Aronofsky as Newspaper Man on Train

James Chinlund as Space Oddity

Olga Merediz as Malin & Block Secretary

Allison Furman as Malin & Block Office Woman

Robert Dylan Cohen as Paramedic Greenhill

Ben Shenkman as Dr. Spencer

Keith David as Big Tim

Dylan Baker as Southern Doctor

Shaun O'Hagan as Ward Attendant Seto

Leland Gantt as Ward Attendant Penn

Bill Buell as Court Doctor

Jimmie Ray Weeks as Prison Guard

Gregg Bello as E.R. Doctor

Henry Stram as ECT Technician

Heather Litteer as Big Tim Party Girl

Jenny Decker as Big Tim Party Girl

Ami Goodheart as Big Tim Party Girl

Nina Zavarin as Big Tim Party Girl

Stanley B. Herman as Uncle Hank

Scott Bader as Party Animal

Jim Centofanti as Party Animal

Scott Chait as Party Animal

Daniel Clarin as Party Animal

Ben Cohen as Party Animal

Eric Cohen as Party Animal

Brett Feinstein as Party Animal

Ricky Fier as Party Animal

John Getz as Party Animal

Andrew Kessler as Party Animal

Ross Lombardo as Party Animal

Carter Mansbach as Party Animal

Scott Miller as Party Animal

Todd Miller as Party Animal

Joshua Pollack as Party Animal

Craig Rallo as Party Animal

Geordan Reisner as Party Animal

Keith Scandore as Party Animal

David Seltzer as Party Animal

Chris Varvaro as Party Animal

Ricardo Viñas as Party Animal

Chad Weiner as Party Animal

Jesse Weissberger as Party Animal

Greg Weissman as Party Animal

Hubert Selby Jr. as Laughing Guard

Lianna Pai as Angelic Nurse

Darren Aronofsky as Visitor (uncredited)