Hugh Laurie as Sam Bell

Joely Richardson as Lucy Bell

Adrian Lester as George

Matthew Macfadyen as Nigel

Yasmin Bannerman as Melinda

Joanna Lumley as Shiela

Rowan Atkinson as Mr. James

Emma Thompson as Druscilla

James Purefoy as Carl Phipps

Tom Hollander as Ewan Proclaimer

Rachael Stirling as Joanna

Dave Thompson as Dave the Comedian / Mrs. Furblob

Stephen Simms as Trevor

John Brenner as Kit

Jaz Wilson as Baby Cuthbert

Richard Leaf as Justin Cocker

Paul Ready as Student Doctor

John Lightbody as Hospital Administrator

Mina Anwar as Yasmin

John Fortune as Acupuncturist

Kelly Reilly as Nimnh

Dawn French as Charlene

Serena Evans as Dr. Cooper

Lisa Palfrey as Jan

Judi Shekoni as Ewan's Posse

Lidija Zovkić as Petra

Paul Tripp as Mr. Furblob