Jake Gyllenhaal as Donnie Darko

Jena Malone as Gretchen Ross

James Duval as Frank

Drew Barrymore as Karen Pomeroy

Beth Grant as Kitty Farmer

Maggie Gyllenhaal as Elizabeth Darko

Mary McDonnell as Rose Darko

Holmes Osborne as Eddie Darko

Noah Wyle as Prof. Kenneth Monnitoff

Katharine Ross as Dr. Lilian Thurman

Patrick Swayze as Jim Cunningham

Daveigh Chase as Samantha Darko

Arthur Taxier as Dr. Fisher

David St. James as Bob Garland

Patience Cleveland as Roberta Sparrow / Grandma Death

Jazzie Mahannah as Joanie James

Jolene Purdy as Cherita Chen

David Moreland as Principal Cole

Kristina Malota as Susie Bates

Marina Malota as Emily Bates

Scotty Leavenworth as David

Phyllis Lyons as Anne Fisher

Gary Lundy as Sean Smith

Alex Greenwald as Seth Devlin

Stuart Stone as Ronald Fisher

Joan Blair as Mystery Woman

Seth Rogen as Ricky Danforth

Mark Hoffman as Police Officer

Jerry Trainor as Lanky Kid

Tom Tangen as Man in Red Jogging Suit

Carly Naples as Suzy Bailey

Lisa K. Wyatt as Linda Connie

Rachel Winfree as Shanda Riesman

Ashley Tisdale as Kim

Tiler Peck as Beth Farmer

Fran Kranz as Passenger

Sarah Hudson as Friend

Alison Jones as Dorky Half-Sister

Lee Weaver as Leroy

Jack Salvatore, Jr. as Larry Riesman