Johnny Depp as Donnie Brasco / Joseph D. 'Joe' Pistone

Al Pacino as Benjamin 'Lefty' Ruggiero

Michael Madsen as Dominick 'Sonny Black' Napolitano

Bruno Kirby as Nicholas 'Nicky' Santora

James Russo as Paulie

Anne Heche as Maggie Pistone

Zeljko Ivanek as Tim Curley

Brian Tarantina as Bruno

Rocco Sisto as Richard 'Richie' Gazzo

Zach Grenier as Dr. Berger

Gerry Becker as Agent Dean Blandford FBI

Robert Miano as Alphonse 'Sonny Red' Indelicato

Paul Giamatti as FBI Technician

Gretchen Mol as Sonny's Girlfriend

Tim Blake Nelson as FBI Technician

Walt MacPherson as Sheriff

Ronnie Farer as Annette

Terry Serpico as Strip Club Owner

Tony Lip as Philip 'Philly Lucky' Giaccone

George Angelica as Big Trin

Val Avery as Santo Trafficante Jr.

Madison Arnold as Jilly

Delanie Fitzpatrick as Daughter

Katie Sagona as Daughter

Sara Gold as Daughter

Larry Romano as Tommy

James McCauley as FBI Agent

James Bulleit as U.S. Attorney

Andrew Parks as Hollman

Keenan Shimizu as Japanese Maitre D'

Rocco Musacchia as Trafficante's Man

Joe Francis as Trafficante's Man

Sal Jenco as Mare Chiaro Bartender

Billy Capucilli as Communion Party Man

Laura Cahill as Communion Party Woman

Doreen Murphy as Mob Girlfriend

Denise Faye as Mob Girlfriend

Elaine del Valle as Mob Girlfriend

John Horton as FBI Director

Dan Brennan as FBI Photographer

LaJuan Carter as Singer

Sandy Barber as Singer

Joyce Stovall as Singer

Frank Pesce as Wiseguy

Randy Jurgensen as Wiseguy

John Di Benedetto as Wiseguy

Richard Zavaglia as Wiseguy

Tony Ray Rossi as Wiseguy

Edward Black as Wiseguy

Gaetano LoGiudice as Wiseguy

Carmelo Musacchia as Wiseguy

Pat Vecchio as Wiseguy

Caleb as The Lion

Flint Beverage as Kings Court Cop (uncredited)

Frank Bonsangue as Sonny Red's Crew (uncredited)

Mark Todd Bruner as FBI Agent (uncredited)

Teresa Giudice as Shocked Stripper (uncredited)

Barry Hirschberg as Background (uncredited)

Jim Lavin as Arresting FBI Officer (uncredited)

Peter O'Hara as Passerby (uncredited)

Antone Pagán as Prison Guard for Pacino and Depp (uncredited)

Garry Pastore as Carmine Galante's Bodyguard

Dale Resteghini as Strip Club Patron (uncredited)

Larry Tobias as Man in Bar (uncredited)

Elle Alexander as Mob Girlfriend

Frankie Cee as Civilian (uncredited)