Matthew Perry as Self (archive footage)

Morgan Fairchild as Self

Martin Estrada as Self - U.S. Attorney for the Central District of California

Katy Forrester as Self - Journalist, The US Sun

Greg Kading as Self - LAPD Detective, Ret.

Deborah Walker as Self - Journalist, The Hollywood Reporter

David Feifel as Self - Kadima Neuropsychiatry Institute

Anna David as Self - Author, Party Girl

Hank Azaria as Self - Actor & Matthew's Friend

Jennifer O'Neill as Self - Former Celebrity Assistant

Jennifer Aniston as Self - Actor & Co-Star (archive footage)

Mark Chavez as Self - Physician (archive footage)

Courteney Cox as Self - Actor & Co-Star (archive footage)

Savannah Guthrie as Self - Co-Host, Today (archive footage)

Kenneth Iwamasa as Self - Matthew's Personal Assistant (archive footage)

Marta Kauffman as Self - Co-Creator, Friends (archive footage)

David Letterman as Self - Host, Late Show with David Letterman (archive footage)

Cody McLaury as Self - Ketamine Overdose Victim (archive footage)

Caitlin Morrison as Self - Matthew's Sister (archive footage)

Keith Morrison as Self - Matthew's Stepfather (archive footage)

John Bennett Perry as Self - Matthew's Father (archive footage)

Salvador Plasencia as Self - Physician (archive footage)

Jasveen Sangha as Self - Ketamine Queen (archive footage)

Diane Sawyer as Self - Journalist, ABC News (archive footage)

Lisa Kudrow as Self (archive footage)

Matt LeBlanc as Self (archive footage)

David Schwimmer as Self (archive footage)

Julia Roberts as Self (archive footage)

Erik Fleming as Self - Director/Alleged 'Street Dealer' (archive footage)