Whoopi Goldberg as Ranger Margaret (voice)

David Spade as Ranger Frank (voice)

E. G. Daily as Tommy Pickles (voice)

Tara Strong as Dilan "Dil" Pickles (voice)

Christine Cavanaugh as Chuckie Finster (voice)

Kath Soucie as Phil / Lil / Betty DeVille (voices)

Cheryl Chase as Angelica Pickles (voice)

Tim Curry as Rex Pester (voice)

Jack Riley as Stuart 'Stu' Pickles (voice)

Busta Rhymes as Reptar Wagon (voice)

Michael Bell as Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)

Joe Alaskey as Grandpa Lou Pickles (voice)

Phil Proctor as Howard DeVille / Igor (voice)

Cree Summer as Susie Carmichael (voice)

Tress MacNeille as Charlotte Pickles (voice)

Melanie Chartoff as Didi Pickles / Minka Kropotkin (voice)

Hattie Winston as Lucy Carmichael (voice)

Andrea Martin as Aunt Miriam (voice)

Tony Jay as Dr. Lipschitz (voice)

Abraham Benrubi as Serge (voice)

Gregg Berger as TV Announcer (voice)

Charlie Adler as United Express Driver (voice)

Mary Gross as Female Guest (voice)

Edie McClurg as Nurse (voice)

Roger Clinton, Jr. as Air Crewman (voice)

Margaret Cho as Lt. Klavin (voice)

Iggy Pop as Newborn Baby (singing voice)

Louis Fresse as Newborn Baby (singing voice)

Lisa Loeb as Newborn Baby (singing voice)

Lenny Kravitz as Newborn Baby (singing voice)

Dawn Robinson as Newborn Baby (singing voice)

Lou Rawls as Newborn Baby (singing voice)

Kate Pierson as Newborn Baby (singing voice)

Cindy Wilson as Newborn Baby (singing voice)

Gordon Gano as Newborn Baby (singing voice)

Laurie Anderson as Newborn Baby (singing voice)

Malik Isaac Taylor as Newborn Baby (singing voice)

Fred Schneider as Newborn Baby (singing voice)

Jakob Dylan as Newborn Baby (singing voice)

Patti Smith as Newborn Baby (singing voice)

Beck as Newborn Baby (singing voice)

Steve Zirnkilton as Reporter (voice)

Frank Welker as Spike / Monkeys / Scar Snout (voice) (uncredited)

Phife Dawg as Newborn Baby (Singing Voice)