E. G. Daily as Tommy Pickles (voice)

Nancy Cartwright as Chuckie Finster (voice)

Kath Soucie as Phil DeVille / Lil DeVille / Betty DeVille (voice)

Dionne Quan as Kimi Watanabe-Finster (voice)

Tim Curry as Nigel Thornberry (voice)

Joe Alaskey as Lou Pickles (voice)

Tress MacNeille as Charlotte Pickles (voice)

Michael Bell as Drew Pickles / Charles 'Chaz' Finster, Sr. (voice)

Julia Kato as Kira Watanabe-Finster (voice)

Phil Proctor as Howard DeVille (voice)

Jack Riley as Stuart 'Stu' Pickles (voice)

Tara Strong as Dil Pickles (voice)

Cree Summer as Susie Carmichael (voice)

Cheryl Chase as Angelica Pickels (voice)

Melanie Chartoff as Didi Pickles (voice)

Lacey Chabert as Eliza Thornberry (voice)

Danielle Harris as Debbie Thornberry (voice)

Jodi Carlisle as Marianne Thornberry (voice)

Flea as Donnie Thornberry (voice)

Tom Kane as Darwin (voice)

Bruce Willis as Spike (voice)

Tony Jay as Dr. Lipschitz (voice)

Ethan Phillips as Toa (voice)

Chrissie Hynde as Siri (voice)