Fernando Fernán Gómez as Don Quijote / Alonso Quixano

Cantinflas as Sancho Panza

María Fernanda D'Ocón as Dulcinea del Toboso / Aldonza Lorenzo

Paca Gabaldón as Altisidora

Ricardo Merino as Bachiller Sansón Carrasco

José Orjas as Juez

Emilio Laguna as Duque

Laly Soldevila as Duquesa

María Luisa Ponte as Ama de Don Alonso Quijano

Valeriano Andrés as Maese Nicolás, barbero

Rafael Hernández as Mozo en la cuadra con Aldonza

Manuel Alexandre as Mozo del juicio ante Sancho Panza

Agustín González as Mayordomo del Duque

Valentín Tornos as Baldomero Fernández, notario

Diana Lorys as Moza del juicio ante Sancho Panza

Javier Escrivá as Miguel de Cervantes

Alberto Fernández as (uncredited)

Serafín García Vázquez as (uncredited)

Luis Morris as (uncredited)

María José Cantudo as (uncredited)