Norm Macdonald as Mitch

Artie Lange as Sam

Jack Warden as Pops

Traylor Howard as Kathy

Christopher McDonald as Travis Cole

Chevy Chase as Dr. Farthing

Don Rickles as Hamilton

Polly Shannon as Toni-Ann

David Koechner as Anton Phillips

Rebecca Romijn as Bearded Lady

Gary Coleman as Self

Ken Norton as Self

Bradley Reid as Mitch (at 8 Years Old)

Matt Steinberg as Mitch (at 16 years old)

Joseph Sicilia as Sam (at 8 Years Old)

Austin Pool as Sam (at 16 Years Old)

Gerry Mendicino as Manetti

A. Frank Ruffo as Aldo

Hrant Alianak as Kirkpatrick

Michael Vollans as Derek (at 10 Years Old)

Grant Nickalls as Jason

Deborah Hinderstein as Charlene

Scott Gibson as Frat Guy

Laura Stone as Veronica

Rummy Bishop as Homeless Guy at Apartment

James Carroll as Middle-Aged Guy

Henry Chan as Doctor at Fat Clinic

Paul O'Sullivan as A.D.

Boyd Banks as Creepy Harry

B.J. McQueen as Big Wet Man

Tony Meyler as Lobby Henchman

Shane Daly as Door Henchman

James Binkley as Unaffected Henchman

Jim Downey as Martin / Homeless Guy

Fred Wolf as Homeless Guy

Wilfrid Bray as Homeless Guy

Jessica Booker as Mrs. Murphy

Johnie Chase as Policeman

Conrad Bergschneider as Policeman

Kay Hawtrey as Gladys

Lloyd White as Ron

Dini Petty as Self

Mike Anscombe as Self

Howard Jerome as Foreman

Arturo Gil as Midget Paul

Joslyn Wenn as Jenkin's Fantasy Girl

Robbie Rox as Huge Prisoner

Chris Gillett as Suit Guy

Kevin Farley as Theater Worker

Sanjay Talwar as Theater Worker

Trevor Bain as Henchman Jenkins

Gord Martineau as Self

George Sperdakos as Opera Critic

Eleanor Davies as Opera Critic's Date

Laura Pudwell as Opera Lady

Emilio Roman as Baritone Errante

George Chuvalo as Ring Announcer

Christine Oddy as Aunt Jenny

Robert Shipman as Crossing Guard

Richard Sali as Ed

Michael A. Miranda as Low Life

Anthony J. Mifsud as Low Life

Cliff Saunders as Thief

Bess Motta as Aerobics Instructor (archive footage)

Arlaine Wright as Aerobics Instructor (archive footage)

Chris Farley as Jimmy (uncredited)

Conrad Goode as John (uncredited)

John Goodman as Mayor Adrian Riggins (uncredited)

Sherry Hilliard as Girl Next Door (uncredited)

Adam Sandler as Satan (uncredited)

Jennifer Steede as Woman at Bar (uncredited)

Uni Park as Saigon Whore