William Powell as Nick Charles

Myrna Loy as Nora Charles

Lucile Watson as Mrs. Marta Charles

Gloria DeHaven as Laura Belle Ronson

Anne Revere as Crazy Mary

Helen Vinson as Helena Draque

Harry Davenport as Dr. Bertram Charles

Leon Ames as Edgar Draque

Donald Meek as Willie Crump

Edward Brophy as Brogan

Lloyd Corrigan as Dr. Bruce Clayworth

Anita Sharp-Bolster as Hilda

Ralph Brooke as Peter Berton

Donald MacBride as Police Chief MacGregor

Morris Ankrum as Willoughby Peavy

Nora Cecil as Miss Peavy

Minor Watson as Sam Ronson

Irving Bacon as Tom

Virginia Sale as Tom's Wife

Asta Jr. as Asta

Joseph Crehan as Clancy - Policeman at Railroad Station (uncredited)

Tom Dugan as Studs Lonnegan (uncredited)

Wally Cassell as Bill Burns (uncredited)

Edward Gargan as Mickey Finnegan (uncredited)

Rex Evans as Fat Man in Train Passageway (uncredited)

Charles Halton as R.T. Tatum (uncredited)

Paul Langton as Tom Clayworth (uncredited)

Etta McDaniel as Ronson's Maid (uncredited)

Clarence Muse as Porter on Train (uncredited)

Robert Emmett O'Connor as Baggage Attendant on Train (uncredited)

Garry Owen as Pool Player (uncredited)

Jack Perry as Man in Pool Hall Brawl (uncredited)

William H. O'Brien as Train Passenger (uncredited)

Oliver Blake as Reporter (uncredited)

Tom Fadden as Train Passenger in Passageway (uncredited)

Sam Flint as Hotel Clerk (uncredited)

Harry Hayden as Train Conductor (uncredited)

Mitchell Lewis as Third Man Outside Barber Shop(uncredited)