Adewale Akinnuoye-Agbaje as Heavy Duty

Christopher Eccleston as McCullen / Destro

Lee Byung-hun as Storm Shadow

Joseph Gordon-Levitt as The Doctor / Rex

Sienna Miller as Ana Lewis / Baroness

Rachel Nichols as Scarlet

Ray Park as Snake Eyes

Jonathan Pryce as U.S. President

Saïd Taghmaoui as Breaker

Channing Tatum as Duke

Arnold Vosloo as Zartan

Marlon Wayans as Ripcord

Dennis Quaid as General Hawk

Grégory Fitoussi as Baron de Cobray

Leo Howard as Young Snake Eyes

Karolína Kurková as Cover Girl

David Murray as James McCullen - 1641

Kevin J. O'Connor as Doctor Mindbender

Gerald Okamura as Hard Master

Brandon Soo Hoo as Young Storm Shadow

Christopher Akers as G.I. Joe Security Tech

Fabrice Baral as CNN Reporter

Michael Benyaer as Flight Control Technician

Peter Breitmayer as Dr. Hundtkinder

Michael Broderick as Screaming Man

Elena Evangelo as White House Staff

Mark Hames as White House Staff

Jacques Frantz as Bastille Prison Warden

Wayne Lopez as G.I. Joe Security Tech

Kellie Matteson as G.I. Joe Control Room Technician

Burton Perez as Bravo Soldier

Bob Rumnock as M.A.R.S. Lab Worker

Robert Russell as Bastille Prison Priest

Ashley Sommers as Little Girl

Michael Sommers as Neo Viper Secret Service

Gunner Wright as Secret Service Agent

Duncan Bravo as Foreign General

Charles Howerton as Foreign General

Robert Almodovar as Foreign General

David Jean Thomas as Foreign General

Ken Thomas as Apache Navigator

Frederic Doss as Apache Navigator

Buzz Covington as Apache Helicopter Pilot

Ron Thompson as Apache Helicopter Pilot

Brendan Fraser as Sgt. Stone (uncredited)

Larry Hama as NATO General (uncredited)