Andree Maranda as Sara

Mitch Cohen as The Toxic Avenger

Jennifer Prichard as Wanda

Cindy Manion as Julie

Robert Prichard as Slug

Gary Schneider as Bozo

Pat Ryan as Mayor Belgoody

Mark Torgl as Melvin

Dick Martinsen as Officer O'Clancy

Chris Liano as Walter Harris

David Weiss as Chief of Police

Dan Snow as Cigar Face

Doug Isbecque as Knuckles

Charles Lee Jr. as Nipples

Patrick Kilpatrick as Leroy

Larry Sulton as Frank

Michael Russo as Rico

Norma Pratt as Mrs. Haskell

Andrew Craig as Fred

Ryan Sexton as Johnny

Sarabel Levinson as Melvin's Mom

Al Pia as Tom Wrightson

Reuben Guss as Dr. Snodburger

Kenneth Kessler as Toxic Avenger's Voice (voice)

Barbara Gurskey as Barbie

Rick Collins as Bully

Randy Schein as Bozo's Friend

Richard Duggan as Ice Cream Man

Donna Winter as Mayor's Secretary

Marisa Tomei as Health Club Girl (uncredited)