Dan Aykroyd as Louis Winthorpe III

Eddie Murphy as Billy Ray Valentine

Ralph Bellamy as Randolph Duke

Don Ameche as Mortimer Duke

Denholm Elliott as Coleman

Kristin Holby as Penelope Witherspoon

Paul Gleason as Clarence Beeks

Jamie Lee Curtis as Ophelia

Alfred Drake as President of Exchange

Bo Diddley as Pawnbroker

Frank Oz as Corrupt Cop

Jim Belushi as Harvey

Al Franken as Baggage Handler #1

Tom Davis as Baggage Handler #2

Maurice Woods as Duke & Duke Employee

Richard D. Fisher, Jr. as Duke & Duke Employee

Anthony DiSabatino as Duke & Duke Employee

Bonnie Behrend as Duke & Duke Employee

Sunnie Merrill as Duke & Duke Employee

James Newell as Duke & Duke Employee

Mary St. John as Duke & Duke Employee

Bonnie Tremena as Duke & Duke Employee

David Schwartz as Duke & Duke Employee

Tom Degidon as Duke Domestic

William Magerman as Duke Domestic

Alan Dellay as Duke Domestic

Florence Anglin as Duke Domestic

Ray D'Amore as Duke Domestic

Bobra Suiter as Duke Domestic

Herb Peterson as Duke Domestic

Sue Dugan as Duke Domestic

Walt Gorney as Duke Domestic

B. Constance Barry as Duke Domestic

P. Jay Sidney as Heritage Club Doorman

Avon Long as Ezra

Tom Mardirosian as Officer Pantuzzi

Charles Brown as Officer Reynolds

Robert Curtis Brown as Todd

Nicholas Guest as Harry

John Bedford Lloyd as Andrew

Tony Sherer as Philip

Robert Earl Jones as Attendant

Robert E. Lee as Cop #1

Peter Hock as Cop #2

Clint Smith as Doo Rag Lenny

Ron Taylor as Big Black Guy

James D. Turner as Even Bigger Black Guy

Giancarlo Esposito as Cellmate #2

Steve Hofvendahl as Cellmate #3

James Eckhouse as Guard

Gwyllum Evans as President of Heritage Club

Eddie Jones as Cop #3

John McCurry as Cop #4

Michelle Mais as Hooker #1

Barra Khan as Hooker #2

Bill Cobbs as Bartender

Joshua Daniel as Party Goer

Jacques Sandulescu as Creepy Man

W.B. Brydon as Bank Manager

Margaret H. Flynn as Duke & Duke Receptionist

Kelly Curtis as Muffy

Tracey K. Shaffer as Constance

Susan Fallender as Bunny

Lucianne Buchanan as President's Mistress

Paul Garcia as Jr. Executive #1

Jed Gillin as Jr. Executive #2

Jimmy Raitt as Ophelia's Client

Kate Taylor as Duke's Secretary

Philip Bosco as Doctor

Bill Boggs as Newscaster

Deborah Reagan as Harvey's Girlfriend

Don McLeod as Gorilla

Stephen Stucker as Stationmaster

Richard Hunt as Wilson

Paul Austin as Trader #1

John Randolph Jones as Trader #2

Jack Davidson as Trader #3

Bernie McInerney as Trader #4

Maurice Copeland as Secretary of Agriculture

Ralph Clanton as Official #1

Bryan Clark as Official #2

Gary Klar as Longshoreman

Afemo Omilami as Longshoreman

Shelly Chee Chee Hall as Monica

Donna Palmer as Gladys

Barry Dennen as Demitri

Murray Bandel as Man at Police Station (uncredited)

Benjean as Stray Dog (uncredited)

John Black as Man Sitting on Couch at Party (uncredited)

John Landis as Man with Briefcase (uncredited)

Shirley Levine as Bag Lady (uncredited)

Charles Pendelton as Cop (uncredited)

Yvonna Russell as Girl in Park (uncredited)

Jan Saint as Man in Police Station (uncredited)

Arleen Sorkin as Woman at Party (uncredited)

Ronald Sylvers as Rolls Royce Driver (uncredited)

Marlene Willoughby as Woman Passed Out on Couch (uncredited)

Jim Gallagher as Duke & Duke Employee