James Spader as Dr. Roger Klink

Lara Flynn Boyle as Dr. Emily Paige

Bill Murray as Ezri Stovall

Melora Walters as Melinda

Megan Mullally as Jennifer Klink

Nathaniel Arcand as Calvin

Nick Offerman as Sheriff Panghorn

Jay Mohr as Dan

Greg Pitts as Deputy Trousdale

Catherine O'Hara as Connie Barker

Daniel Libman as Dr. Clark

Don MacKay as Dr. Fromm

Paul Schulze as Larry

Phil LaMarr as Joel Johnson, Jr.

Hart Bochner as Felix

Kathryn Erbe as Helen

Kathleen Robertson as Grace

Anjul Nigam as Jarred