Terumi Matthews as Madonna

Wendie Malick as Camille Barbone

Jeff Yagher as Paul

Diana Leblanc as Ruth Novak

Dean Stockwell as Tony Ciccone

Nigel Bennett as Bennett

Dominique Briand as Toussant

Don Francks as Jerome Kirkland

Tom Melissis as Stu

Christian Vidosa as Emmerich

Rod Wilson as Mitch Roth

Kenner Ames as Donut Manager

Dino Bellisario as Brad Raines

Leo Burns as Church Usher

Mischke Butler as Doo-wop Singer

Kelly Fiddick as Landlord

Gil Filar as Madonna's Brother

Maia Filar as Madonna at Age 10

Diego Fuentes as Salvador

Matthew Godfrey as Peter Barbone

Fairy Gutierrez as Bartender

Robert Hollinger as Waiter

Ephraim Hylton as Thom Hillman

Olly Jasen as Nurse

Glen Kotyk as Choreographer

Bradford May as Man Backstage

Carlos Morgan as Doo-wop Singer

Evon Murphy as Bette Ciccone

Jenny Parsons as Madonna Sr.

Les Porter as Building Manager

Cynthia Preston as Jude O'Mally

Mario Romano as Cab Driver

Christopher Rouse as Doo-wop Singer

Stephane Scalia as Madonna at Age 4

Victoria Tengelis as Registration Clerk

Robert Weiss as Talent Coordinator

Chandra West as Kelsey Lee

Rob Wilson as Biker

Jeff Woods as Flynn

Dave Diamond as The Breakfast Club

John 'Zero' Picard as The Breakfast Club