Nicolas Cage as Cameron Poe

John Cusack as Agent Vince Larkin

John Malkovich as Cyrus "The Virus" Grissom

Ving Rhames as Nathan "Diamond Dog" Jones

Mykelti Williamson as "Baby-O" O'Dell

Dave Chappelle as "Pinball" Parker

Colm Meaney as Agent Duncan Malloy

Monica Potter as Tricia Poe

Landry Allbright as Casey Poe

Rachel Ticotin as Guard Sally Bishop

Steve Buscemi as Garland Greene - "The Marietta Mangler"

Nick Chinlund as William "Billy Bedlam" Bedford

M.C. Gainey as "Swamp Thing"

Danny Trejo as "Johnny-23"

Renoly Santiago as "Sally-Can't Dance"

Steve Eastin as Guard Falzon

Brendan Kelly as Conrad

Jesse Borrego as Francisco Cindino

Carl Ciarfalio as Con #1

Mongo Brownlee as Ajax

José Zúñiga as Sims

Ned Bellamy as Chopper Pilot

John Marshall Jones as Gator

John Roselius as Devers

Fredric Lehne as Pilot

Martin McSorley as Co-Pilot

Dylan Haggerty as Starkey

Dan Bell as Fuel Jockey

Bob Stephenson as Ted, the Pilot

Scott Ditty as Bus Guard

Tommy Bush as Sheriff

Lauren Pratt as Debbie (6 Yrs Old)

Steve Hulin as Ronnie

Don C. McGovern as Smoke

Angela Featherstone as Ginny

Doug Hutchison as Donald

Jeris Poindexter as Watts

David Ramsey as Londell

Conrad Goode as Viking

Emilio Rivera as Carlos

Mario Roberts as Mongoose (Stunt)

Ty Granderson Jones as Blade

Earl Billings as Guard

Greg Collins as Guard

Billy Devlin as Guard

Mark Ginther as Guard

Joseph Patrick Kelly as Guard

Jeff Olson as Uncle Bob

Dawn Bluford as Female Baggage Handler

Charlie Paddock as Transportation Officer #1

Randee Barnes as Stickman

Don S. Davis as Man In Car

Barbara Sharma as Woman In Car

Thomas Rosales Jr. as Cindino Gunman (Stunts)

Eddie Perez as Cindino Gunman (Stunts)

Scott McCoy as Cindino Gunman (Stunts)

Brian Hayes Currie as Cop In Vegas

Ashley Smock as Huey Pilot

Charles Lynn Frost as DEA Agent

Joey Miyashima as Tech Guy

Scott Burkholder as Air Traffic Controller

Kevin Cooney as Judge

Gérard L'Heureux as Guard Renfro

Pete Antico as Guard Garner

John Robotham as Guard Ryan

Gilbert Rosales as Ramirez (Stunt)

Richard L. Duran as Warlock (Stunt)

George Randall as Old Con on Plane

Jamie Bozian as Con

Harley Zumbrum as Con

Doug Dearth as Con

David Roberson as Supervisor

Alexandra Balahoutis as Waitress

Dick 'Skip' Evans as Airplane Pilot

Sheldon Worthington as Co-Pilot

Robert Taft as Soldier

Robert White as Soldier

Chris Ellis as BOP Official Grant

John Campbell as BOP Bus Driver

Brian Willems as Paramedic

Bill Cusack as Paramedic

Dabbs Greer as Old Man Under Truck

Marco Kyris as Cindino's Pilot

Kevin Gage as Billy Joe (uncredited)

Dennis Burkley as Dale (uncredited)