Kamal Haasan as Govindarajan Ramaswamy / Rangaraja Nambi / George W. Bush / Avtaar Singh / Balram Naidu / Christian Fletcher / Shinghen Narahasi / Krishnaveni / Vincent Poovaragavan / Kalifullah Mukhtaar

Asin Thottumkal as Kodhai Radha / Andal

Mallika Sherawat as Jasmine

Jaya Prada as Ranjitha Singh

Napoleon as Kulothunga Chola II

P. Vasu as J. Ragavendra (Jaa Raa)

Raghuram as Appa Rao

Chakri Toleti as Sairam

Shammu as Assistant Biotechnologist

M. S. Bhaskar as Broadway Kumar

Vaiyapuri as Prabhu

Chitti Babu as Ekambaram

Santhana Bharathi as J. Ragavendra's brother-in-law

Sundarrajan as Member of Legislative Assembly

Nagesh as Sheikh Mukhtaar

K R Vijaya as Megha Mukhtaar

Ramesh Khanna as Doctor

David W. Scott as Lab Tech / Detective

Brian Jennings as Chief of Home Land Security

Rekha as Meenakshi Ragavendra