Martha Plimpton as Samantha

Dermot Mulroney as Henry

Héctor Elizondo as Walter

Mary Kay Place as Marilyn

Ione Skye as Elaine

Marvin Silbersher as Milos

I.M. Hobson as Father O'Rourke

Maryedith Burrell as Charlotte Otto

Robert Picardo as Neil Otto

Shay Astar as Young Samantha

Cameron Williams as Young Henry

Dody Goodman as Mrs. Higgins

Randy Pelish as Ed Perlmutter

Sandra Kinder as Phyllis Perlmutter

Jack Blessing as Herman Hathaway

Earl Boen as Support Group Leader

Lora Staley as TV Reporter

Karie Prescott as Quartet Violist

Gabriel Martínez as Quartet Violinist

Alan Toy as Manpower Dispatcher

Pablo Bryant as Ivan

Philip Tanzini as College Boyfriend

Steve Wilcox as College Boyfriend

David Rogge as College Boyfriend

Taj Johnson as College Boyfriend

Adam Biesk as College Boyfriend

Bea Marcus as Mrs. Schtumer

Eric Gilliland as Hendricks