Tom Cruise as Narrator (voice)

James H. Newman as Self - Mission Specialist, STS-88

Jerry L. Ross as Self - Mission Specialist, STS-88

Robert D. Cabana as Self - Commander, STS-88

Koichi Wakata as Self - Mission Specialist, STS-92

Brian Duffy as Self - Commander, STS-92

Pamela Ann Melroy as Self - Pilot, STS-92

Marc Garneau as Self - Mission Specialist, STS-97

Joseph R. Tanner as Self - Mission Specialist, STS-97

Brent W. Jett Jr. as Self - Commander, STS-97

Michael J. Bloomfield as Self - Pilot, STS-97

Marsha Ivins as Self - Mission Specialist, STS-98

Yuri Valentinovich Lonchakov as Self - Mission Specialist, STS-100

Thomas D. Jones as Self - Mission Specialist, STS-98

John L. Phillips as Self - Mission Specialist, STS-100

Kent V. Rominger as Self - Commander, STS-100

James D. Wetherbee as Self - Commander, STS-102

James M. Kelly as Self - Pilot, STS-102

Michael L. Gernhardt as Self - Mission Specialist, STS-104

Janet Lynn Kavandi as Self - Mission Specialist, STS-104

Steven W. Lindsey as Self - Commander, STS-104

Charles Owen Hobaugh as Self - Pilot, STS-104

Yuri Pavlovich Gidzenko as Self - Soyuz Commander, Expedition One

Sergei Krikalev as Self - Flight Engineer, Expedition One

William M. Shepherd as Self - Commander, Expedition One

Susan Helms as Self - Flight Engineer, Expedition Two

James S. Voss as Self - Flight Engineer, Expedition Two

Yury Usachev as Self - Commander, Expedition Two

Greg Jurls as Self - Video Producer

James Arnold as Self

Leroy Chiao as Self

Kenneth D. Cockrell as Self

Robert L. Curbeam Jr. as Self

Umberto Guidoni as Self

Chris Hadfield as Self

Michael E. López-Alegría as Self

William Surles McArthur Jr. as Self

Scott E. Parazynski as Self

Mark L. Polnaksy as Self

James F. Reilly II as Self

Paul William Richards as Self

Andrew S.W. Thomas as Self

Peter J.K. Wisoff as Self