Sandra Bullock as Margaret Tate

Ryan Reynolds as Andrew Paxton

Malin Åkerman as Gertrude

Craig T. Nelson as Joe Paxton

Mary Steenburgen as Grace Paxton

Betty White as Grandma Annie

Denis O'Hare as Mr. Gilbertson

Oscar Nuñez as Ramone

Aasif Mandvi as Bob Spaulding

Michael Nouri as Chairman Bergen

Gregg Edelman as Lead Counsel Malloy

Michael Mosley as Chuck

Dale Place as Jim McKittrick

Alicia Hunt as Coffee Barista

Alexis Garcia as Immigration Clerk

Kortney Adams as Colden Books Receptionist

Chris Whitney as Medivac Pilot

Jerrell Lee Wesley as Jordan

Phyllis Kay as Mrs. McKittrick

Kate Lacey as Party Guest

Gene Fleming as Store Owner

Mary Linda Rapelye as Executive Secretary

Anne Fletcher as Jill

B. Johnson as Guy in Office

John Franchi as Taxicab Driver (uncredited)

Dan Griffin as Businessman / Pedestrian on Sidewalk (uncredited)

London Hall as Wedding and Reception Guest (uncredited)

Dan Marshall as Lawyer at Publishing Company (uncredited)

Ron Murphy as Wedding Guest (uncredited)

Niecy Nash-Betts as Stewardess (uncredited)

Thomas Olson as Party Guest (uncredited)

Donna Glee Reim as Reception Guest (uncredited)

Rich Skinner as New York Cab Driver (uncredited)

Ylian Alfaro Snyder as Immigrant at INS Office (uncredited)

Uzimann as Pedestrian (uncredited)

Larry Vigus as Party Guest (uncredited)